Retraction notice to “Circulating adhesion molecules in cardiac operations: influence of high-dose aprotinin” [Ann Thorac Surg 59 (1995) 100-105]

APROTININ: EFFECTS ON BLOOD LOSS AND FRESH FROZEN PLASMA REQUIREMENT IN CARDIAC OPERATIONS

 ABSTRACT Background: Aprotinin has been used increasingly to reduce postoperative blood loss in open-heart operations due to the potentialities for complications and high cost, it would seem reasonable to use aprotinin more selectively in small doses in the prime solution of the pump. Methods: We prospectively studied the effect of preoperative low dose aprotinin [2 million units (230mg)] on b...

Influence of ultra-low dose Aprotinin on thoracic surgical operations: a prospective randomized trial

BACKGROUND The blood saving effect of aprotinin has been well documented in cardiac surgery. In thoracic surgery, very few recent studies, using rather high doses of aprotinin, have shown a similar result. In a randomized prospective trial, we have tested the influence of aprotinin using an ultra-low dose drug regime. METHODS Fifty-nine patients, mean age 58 +/- 13.25 years (mean +/- SD) unde...

Retraction Notice - 2

Retraction Notice - 3

Circulating adhesion molecules in cystic fibrosis.

A marked influx of inflammatory cells occurs into the airways of patients with cystic fibrosis (CF), which may contribute to the development of lung injury. Leukocyte-endothelial adhesion molecules play a crucial role in the recruitment of inflammatory cells, and soluble forms of these molecules have been shown to increase in several inflammatory diseases. By using a capture ELISA, we determine...